High Purity Pure Diphenhydramine Hydrochloride powder CAS 147-24-0-Pharmceutical Intermediate-Shandong Yifan Chemical Technology co.,Ltd.-

High Purity Pure Diphenhydramine Hydrochloride powder CAS 147-24-0

Diphenhydramine Hydrochloride 147-24-0

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol .

Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.

Product Name	Diphenhydramine Hydrochloride
CAS No.	147-24-0
Chemical formula	C17H22ClNO
Purity	99%
Appearance	White crystalline powder
Molecular weight	291.82

Specification

Items	Specification	Results
Appearance	White or almost white crystalline powder	Complies
Solubility	Very soluble in water,freely soluble in alcohol	Complies
Identification	UV	Complies
	IR	Complies
	It responds to the tests for chloride	Complies
Melting range	168-172°C	168-169°C
Appearance of solution	Clear, NMTBY6	Complies
Acidity or alkalinity	NMT 0,5ml ofO.OlM NaOH	Complies
Related substance	Impurity A: 0.5% max	0.04%
	Any other unspecified impurity: 0.3% max	Not Detected
	Total impurities: 1.0% max	0.04%
Loss on drying	0.5% max	0.2%
Sulphated ash	0.1% max	0.04%
Assay(Dried substance)	99.0^101.0%	100.8%
Residual solvent	Ethanol: 0.5% (5000ppm) max	0.03%
	Toluene: 0.089% (890ppm) max	0.0004%

Function

1.Can eliminate all kinds of allergy symptoms.Its central inhibitory effect is significant, but not as good as promethazine hydrochloride;Still have sedative. 2.Prevent dizzy move and antiemetic effect, also have fight choline effect. 3.Can alleviate bronchial smooth muscle spasm.For various allergic skin diseases, such as urticaria, insect bite. 4.Also used for motion sickness, nausea and vomiting.

Application

1.Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

2.Diphenhydramine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

3.Diphenhydramine is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson's disease.

4.Diphenhydramine may also be used for purposes not listed in this medication guide.

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